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KMID : 0356620130280040331
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Journal of Korean Society of Endocrinology
2013 Volume.28 No. 4 p.331 ~ p.334
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Rhabdomyolysis and Acute Kidney Injury Associated with Hypothyroidism and Statin Therapy
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Ahn Pyoung
Min Hyun-Jun
Park Sang-Hyun
Lee Byoung-Mu
Choi Myung-Jin
Yoon Jong-Woo
Koo Ja-Ryong
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Abstract
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Rhabdomyolysis is a syndrome involving the breakdown of skeletal muscle that causes myoglobin and other intracellular proteins to leak into the circulatory system, resulting in organ injury including acute kidney injury. We report a case of statin-induced rhabdomyolysis and acute kidney injury that developed in a 63-year-old woman with previously undiagnosed hypothyroidism. Untreated hypothyroidism may have caused her hypercholesterolemia requiring statin treatment, and it is postulated that statin-induced muscle injury was aggravated by hypothyroidism resulting in her full-blown rhabdomyolysis. Although this patient was successfully treated with continuous venovenous hemofiltration and L-thyroxin replacement, rhabdomyolysis with acute kidney injury is a potentially life-threatening disorder. Physicians must pay special attention to the possible presence of subclinical hypothyroidism when administering statins in patients with hypercholesterolemia.
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KEYWORD
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Hypothyroidism, Rhabdomyolysis, Statins
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